2 posts tagged “PD research”

A possible Parkinson’s disease/melanoma link? Time for a skin check

Posted 11 months ago by

Now that summer has passed, have you had your skin examined? Studies have shown that people with Parkinson’s disease (PD) may have an increased risk for melanoma, so skin screenings are extra-important. Take a look at recent research and get some tips on monitoring your moles and skin.

Studies show…

A 2017 Mayo Clinic study found that people with either PD or melanoma are four times as likely to receive a diagnosis of the other disease. The researchers say the PD drug levodopa (which some people believe may play a role in melanoma risk) is not likely a factor in the PD/melanoma connection, according to McKnight’s. They found that the majority of melanomas were diagnosed before the diagnosis or treatment of Parkinson’s disease, so taking levodopa doesn’t appear to be a risk factor.

Future research should focus on genes, immune responses and environmental exposures that could cause the relationship, the researchers say.

Know your “ABCDEs”

Check out the Skin Cancer Foundation’s “ABCDEs of Melanoma” (click here to see images of examples), and make an appointment right away if you spot any of these warning signs:

A = asymmetry. Malignant moles tend to have an odd shape.

B = border. The edges of an early melanoma may be uneven or “scalloped.”

C = color. Watch out for moles that are a spotty mix of colors (from tan to black, or even shades of red, white or blue).

D = diameter. Melanomas are usually larger in diameter than a pencil eraser (but may be smaller early on).

E = evolving. Keep an eye out for any changes in your moles, such as size, shape, color, elevation, or another trait, or new symptoms such as bleeding, itching or crusting.

Also, keep in mind these other risk factors for melanoma, according to the Michael J. Fox Foundation for Parkinson’s Research:

  • Ultraviolet (UV) light exposure (psst: use sunscreen and protective clothing)
  • Caucasian race
  • Older age
  • Male
  • Family history of melanoma or personal history of melanoma or other skin cancers

The Fox Foundation is currently funding studies on the PD/melanoma connection, including one exploring the role of alpha-synuclein (a sticky protein) in both conditions, and others examining the genes or gene mutations involved in the two conditions. Learn more here.

On PatientsLikeMe

Some members report having both PD and melanoma. “I encourage everybody to go to a dermatologist, who has observed thousands of moles, on various skin types, and pay them to do a body scan,” says one member with PD and melanoma (fortunately, a biopsy showed his cancer had not spread). “Melanoma is not slow progressing like Parkinson’s.”

Has your doctor ever mentioned melanoma risk? Join PatientsLikeMe or log in to talk about Parkinson’s and melanoma in the PD forum.


Spill the beans: How do caffeine and Parkinson’s disease interact?

Posted May 14th, 2018 by

Do you crave that cup (or more) of joe each day? Or a spot of tea or chunk of chocolate? Research about caffeine and Parkinson’s disease (PD) has been all over the map. What have studies shown? And what’s the PatientsLikeMe community’s take on caffeine and its effects when you’re living with PD? Take a peek.

Mixed findings on symptom relief

Past research showing that moderate caffeine intake may help protect against PD (particularly in men) has turned on a steady drip of studies about other caffeine/PD connections or interactions.

A small-scale 2012 study published in the journal Neurology found that moderate amounts of caffeine may help improve motor symptoms of Parkinson’s disease. But the study was relatively short (three weeks) and small (61 patients), so researchers concluded that there should be a larger long-term trial on caffeine and PD.

The lead researcher, Ronald Postuma, M.D. (an associate professor of neurology at McGill University Health Center in Montreal), conducted a follow-up study on a larger scale — involving 121 participants for up to 18 months — and the results of the September 2017 study did not uphold the findings of the 2012 study.

“Caffeine made no difference to Parkinson’s,” he says, noting that the results of the 2012 study made a bigger splash than intended. “The news media picked it up, and all of a sudden I’ve got all of my patients drinking coffee, which I never intended,” Dr. Postuma tells WebMD. “We always have to verify things.”

New findings on caffeine as a biomarker

Another recent caffeine/PD study that’s created a buzz is one published in January 2018 in Neurology that shows caffeine could be a biomarker of PD, meaning it could be a possible predictor or diagnostic blood test down the road, if more research pans out.

In the Japanese study involving 139 people (men and women, both with and without PD), those with Parkinson’s disease had significantly lower levels of caffeine and related byproducts in their blood, even when consuming the same amount of caffeine (the equivalent of about two cups of coffee per day).

But the study also had limitations, including the fact that people with severe PD weren’t a part of the research, and all participants were taking PD medication (so these drugs could possibly affect caffeine metabolism).

The Michael J. Fox Foundation called the study’s findings “very intriguing” and is reportedly working on a “rapid replication” of the research.

What’s the takeaway from all this research?

The Parkinson’s Foundation sums it up like this: “The bottom line from all of the available research is that the epidemiologic link between caffeine and a potential lower risk of developing Parkinson’s disease is not likely related to a symptomatic effect. If you have Parkinson’s, drinking coffee will not worsen your symptoms, in most cases… Consumption of coffee or tea seems to reduce the risk of developing Parkinson’s. Once you have been diagnosed with Parkinson’s disease, no matter how much time you spend in a coffee shop, you can no longer alter your risk profile.”

Among the general population, drinking coffee appears to have at least a few health perks. Nutrition experts at Harvard University say that, in addition to lowering the risk for PD, drinking coffee appears to protect against type 2 diabetes and liver cancer, and it’s generally a good beverage choice for healthy people (as long as it’s not loaded with fat/cream and sugar, interrupting sleep, or causing tremors — which can occur even in healthy people who consume too much caffeine).

Keep in mind that caffeine levels vary by brand and type of drink (for example, espresso and mocha drinks contain more). Talk with your health care team about your caffeine intake, timing with medications, and any symptoms you think may be associated with it.

Join PatientsLikeMe today to connect with others on topics like this (logged-in members can access the following links)! See what members with PD are saying about:

Some members have found that caffeine makes their tremors worse, while others say they’re not sure how it affects them (and besides, they’ll never give up their “morning joe”). A few have mentioned that they’ve tweaked their routine — having a bit of coffee only after they’ve taken their medication.

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